Accumulation

Definition of Accumulation from the PharmacyDictionary.in

Accumulation

“Accumulation” in a pharmaceutical context refers to the increase in the concentration of a drug in plasma or tissue over time. This typically occurs when the rate of drug administration exceeds the rate of drug elimination. Understanding drug accumulation is crucial for determining the appropriate dosage and frequency of administration for a medication to maintain its therapeutic effect while minimizing side effects. It’s an important concept in pharmacokinetics, the study of how the body absorbs, distributes, metabolizes, and excretes drugs. Example: Increase in the concentration of a drug in plasma or tissue.

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